17-Apr-2024
HomeENGLISHUnraveling T Cell Responses: Tissue Elasticity Determines Fate

Unraveling T Cell Responses: Tissue Elasticity Determines Fate

Researchers at Harvard’s Wyss Institute and Harvard SEAS, led by David Mooney, aimed to decipher how mechanical cues in different tissues influence T-cell behavior. They devised a tissue-mimicking hydrogel model to showcase that highly elastic tissues prompt T cells to develop into effector-like cells, boasting potent capabilities for eliminating tumors.

Conversely, in more viscous tissues, T cells tend to transform into memory-like T cells, retaining a long-lasting immune memory.

This groundbreaking study sheds light on the critical role of tissue elasticity in determining the fate and function of T cells, offering insights for advancing immunotherapeutic strategies.

For a detailed story, visit: Hindustan Times

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